Cristiano Ronaldo scored twice at Celta Vigo to ensure Real Madrid need just a point from their weekend game at Malaga to win the LaLiga title for the first time in five years.
All three relegated sides have paid the price for their mistakes, with Sporting turning their back on home-grown talent for a group of players who were not prepared to roll up their sleeves when the going got tough.
Defender Nacho Fernandez put Real ahead in the 10th minute with some quick thinking from a free-kick, sidefooting the ball into the bottom corner and flummoxing Sevilla, who were still preparing their wall.
Los Blancos will be without Gareth Bale and Dani Carvajal for the tie.
Montenegro forward Stevan Jovetic was arguably the best player for Sevilla, scoring a goal and nearly scoring several more. But still Sevilla threatened and again Jovetic hit the crossbar from a delicate chip with Navas beaten.
On the domestic front, the hosts head into the final two matchdays with nothing to play for, however Zidane warned: "We know that it'll be tough because Celta are a good side and they'll give their all".
"Such misses aren't normal for me", he said.
That goal from Ronaldo could be the goal that all but seals the La Liga title in Real's favour.
James Rodriguez waved the fans a long goodbye, seeming as if it is his last game at the Bernabeu.
Despite a revival of fortunes recently, which has seen him score seven goals in his last 10 games, James has been subject to months of speculation linking him with a move overseas, with Manchester United reportedly the most likely suitors.
The game was in the balance for a while before Ronaldo netted his second in the 78th minute and Tony Kroos rounded off the victory with six minutes remaining.
"It was important for us to win and we're really pleased with the three points".
Real Madrid will play their most crucial game in Spain's Premier Division when they visit Celta Vigo on Wednesday night. A win and a draw will be enough for Los Blancos. Barcelona meanwhile, have beaten Eibar home and away on the past occassions.
A report in Don Balon today claims that the 25-year-old will only join the Old Trafford club if they qualify for next season's Champions League, according to the Daily Express.