Sen. Chris Coons (D-Del.) told CNN's "New Day" on Wednesday that Ossoff's loss is "not surprising", given that he was running for a seat that's been held by a Republican for nearly four decades.
Handel won with about 53 percent of the vote to Ossoff's 47 percent.
Trump, five months into his presidency, has had scant legislative success in enacting his agenda, with Democrats blocking or stalling many of his proposals. "However, Democrats have overperformed in heavily Republican districts in every special election, even if they haven't won".
The victories could boost Republicans' confidence as they struggle to advance health and tax legislation that has been bogged down by infighting and investigations into whether Trump's campaign colluded with Russian Federation in last year's presidential election. "Trump agenda is popular", he posted in a re-tweet of one of his previous messages. "If we do do that, I think we've got a really strong chance of taking back the House", Coons said. "Because in these United States of America, no one - no one - should ever feel their life threatened over their political beliefs and positions".
In 2009, the first year of Barack Obama's presidency, there were five congressional special elections, including one in a red district in upstate NY, and Democratic candidates won all five.
Handel, who left an abusive home as a teenager, will be the first Republican woman to represent Georgia in Congress.
The difference between those two districts and the Georgia Sixth is that they both supported Trump by wide margins, despite all of these districts heavily supporting the Republican candidate for Congress in the general election. Rep. Seth Moulton (D-Mass.) tweeted Tuesday night that he hoped the Georgia race would be a "wake up call for Democrats - business as usual isn't working". Democrats need a lot more candidates with resumes like hers if they want to win, and close losses in these special elections might lead them to conclude they should stick with their safe seats in state or local government rather than take a risk in 2018.
Acknowledging the historic moment while giving her victory speech in Georgia on Tuesday, she said: "Tonight reminds me, anything is possible".
House Speaker Paul Ryan congratulated Handel on a "hard-earned" victory. Pundits labeled it a harbinger for the 2018 midterms, arguing a win by 30-year-old Democrat Jon Ossoff could signal a "blue wave" next November. "But this is the beginning of something much bigger than us".
Especially in a constituency like Georgia, which has been in Republican hands since 1979. Trump was in Louisville to attend a rally at the Kentucky Exposition Center.
Handel is the oasis in Trump's desert of losses. She rarely mentioned the administration, despite holding a closed-door fundraiser with the president earlier this spring.
Democrats attacked her record, including increasing spending as secretary of state.
"I need to also thank Speaker Ryan and the House leadership and so numerous members across this country". Her supporters reacted with cries of "Trump, Trump, Trump!" The Republican campaign establishment, however, helped make up the difference.
More than $3 million was spent on Quist's unsuccessful effort.
On policy, Handel mostly echoes the GOP line.