Rafael Nadal has now dropped two sets in a row after having won his previous 28 in Grand Slam action. In the last 10 matches of Roger Federer, he has won nine matches and lost one match.
But the bustling Spaniard has played some sensational tennis in his opening three matches and faces Luxembourg veteran Gilles Muller on Monday for a place in the quarter-finals.
"Against Rafa", said the man he defeated in the third round, 30th-seeded Karen Khachanov, "if you give him time, he can destroy you". Djokovic struggled prior to Wimbledon and has talked about taking a break from the sport, but he's looked in fine form on these grass courts thus far. "I'm pretty pleased with that", Dimitrov said.
"I'm just so happy to be in the quarters".
Five-times champion Venus Williams is, at 37, the oldest player in more than two decades to reach the last eight.
Federer's first Wimbledon victory came in 2003 and his latest came in 2012, when he beat out Andy Murray.
Milos Raonic is coming off a five sets win over Alexander Zverev that took 51 games to decide.
Murray will play Sam Querrey on Wednesday. She is playing at the grass-court major for the 20th time in her career.
Murray and Paire share Centre Court billing with Williams, who faces Croatian teenager Ana Konjuh, and Roger Federer against Grigor Dimitrov.
The lack of light and tournament curfew made it impossible to start playing after Nadal's loss, however.
No. 3 Karolina Pliskova (PLIHSH'-koh-vah) has become the highest-seeded player to fall at Wimbledon, losing to Magdalena Rybarikova in the second round. "I mean, the courts are always flawless here".
He won the decider at love, acing three points against the 10th-seeded Zverev.
At Wimbledon, Ostapenko is into the quarterfinals for the first time. "I've managed it well and I think I've played some good stuff. I'm doing well so hopefully I keep it up".
Standing in the way of Konta is the imposing but unpredictable talent of Caroline Garcia, the 21st seed from France.
Its the second Monday of Wimbledon, and this is one of the most famous days in tennis, its a special day because its the only one of the 4 grand slams that has the womens and mens last 16 on the same day. She has never advanced past that stage.