Murray said: 'It's tough today.
No other man has taken more Slams to reach their first semifinal, as Querrey's 42 tops Mark Woodforde's previous record of 38.
"As the match kept going, I just felt more and more confident, more and more like I belonged", said the 24th seed.
Like I said, I mean, Sam served great.
Querrey, who ended Novak Djokovic's title defence a year ago, took advantage of Sir Andy's injury problems to clinch a 3-6, 6-4, 6-7, 6-1, 6-1 triumph on Centre Court at the All England Lawn Tennis Club. The three-time Wimbledon champion, who would have regained the world No 1 ranking if he had won the tournament, was trailing 7-6, 2-0 when he called it quits on Court One. Over the final two sets, Querrey hit 30 winners to just four unforced errors.
Novak Djokovic also went out on Wednesday on a day of surprises, retiring from his match against Tomas Berdych. Federer's opponent is Milos Raonic - the third time in four years they'll face each other at the tournament. Tennis player from Monaco persevered in the fourth set, but for the final game of it is not enough.
The semifinals is shaping up to be thrilling at Wimbledon this year.
"Before the tournament, it was very short-term thinking because you want to play Wimbledon", he added.
Keep fighting the good fight, Murray.
However, the champion's afternoon on Centre Court began to unravel as his movement became increasingly limited. Should he survive that, he'll have to play the victor of a section of the bracket that includes Djokovic (2), Roger Federer (3), Milos Raonic (6), and Tomas Berdych (11). "It always comes to an end", said Murray on Wednesday. The exit of Andy Murray no doubt makes either Federer or Djokovic the favorite to win the title.
29-year-old Querrey managed to hold his nerve when he needed to most and, in the end, he simply brushed aside the clearly injured world No.1.