Nominees will be announced across a range of categories from best drama and best comedy to the best lead and supporting actors from both genres.
"Only in my dreams could I have imagined this", the 13-year-old actress said. "And I think there is a place for television that is for everybody, art that is for everybody, that also hopefully can live in the conversation with the darker, edgier stuff".
Pamela Adlon's "Better Things" is a fun and amusing series, but I honestly didn't think it was on the radar this year.
Television Academy Chairman and Chief Executive Officer Hayma Washington also plans to join Chlumsky and Moore at the nominations ceremony, which will stream live on Emmys.com. and on Facebook at 8:30PT/11:30ET.
But he faces competition for the elusive statuette from Sterling K Brown ("This Is Us"), Bob Odenkirk ("Better Call Saul") and last year's victor Rami Malek ("Mr. Robot").
It was a insane season, but House of Cards squeaked into the Outstanding Drama category, leaving The Americans, The Leftovers, and 13 Reasons Why without a spot in the coveted category.
The nominations for "This Is Us", including acting nods for stars Milo Ventimiglia, Sterling K. Brown and Chrissy Metz, make the show the first from a USA network to enter the Emmy drama series contest since CBS's "The Good Wife" in 2011.
Guest actors Gerald McRaney, Denis O'Hare and Bryan Tyree Henry will compete with Ben Mendelsohn, BD Wong and Hank Azaria.
Streaming upstart Netflix followed with 91 and NBC at 60. Each has won seven acting Emmys in all, placing them one behind record holder Cloris Leachman.
Among the actresses nominated for Comedy are Jane Fonda and Lily Tomlin for GRACE AND FRANKIE and SIX DEGREES OF SEPARATION's Allison Janney for MOM. "You saw Samantha Bee get her first nomination". Left out: "The Tonight Show Starring Jimmy Fallon".
CBS' "The Amazing Race" is expected to again be among the nominees for outstanding reality-competition program.
She was nominated in the outstanding guest actress in a comedy series category for her role in Amazon's "Catastrophe".
Actress, Limited Series or Movie: Felicity Huffman, "American Crime"; Nicole Kidman, "Big Little Lies"; Reese Witherspoon, "Big Little Lies"; Carrie Coon, "Fargo"; Jessica Lange, "FEUD: Bette and Joan"; Susan Sarandon, "FEUD: Bette and Joan".