"As Minister of Defense and as a citizen I say this is a insane act, an act of supreme extremism", CNN quoted Padrino as saying.
After US President Donald Trump refused to rule out military intervention in Venezuela, the South American country's defence minister has labelled his comment "an act of craziness".
"This is our neighbor", Trump said in reference to Venezuela.
"Sanctions will worsen the situation of the people of Venezuela, who are already suffering from crippling inflation and a lack of access to adequate food and medicine".
Venezuelan Foreign Minister Jorge Arreaza has issued a statement on behalf of the nation in response to U.S. President Donald Trump's recent threat, vowing to defend the South American country's sovereignty at all costs against foreign hegemony.
But Venezuela is a major OPEC member and supplies the USA with around 740,000 barrels per day - something the U.S. did not slap sanctions on. Maduro has been called a dictator by USA leaders as well as some of his own people.
"A military operation and military option is certainly something that we could pursue". Needless to say, the Venezuelan leader who was in dire straits just got a shot in the arm from the US president.
Trump's military warning came two days after his administration imposed new sanctions on Venezuela, targeting members of a loyalist assembly installed last week to bolster what Washington calls Maduro's "dictatorship".
Donald Trump has said U.S. military intervention is an option in response to Venezuela's descent into political chaos.
The power struggle between the government and the opposition has led to months of violent confrontations that have left more than 100 people dead, including protesters, government supporters and security forces.
Elias Jaua, head of the Presidential Commission for the National Constituent Assembly, said that the ANC did not need the recognition of "any government".
Mr Trump described the situation in Venezuela as a very risky mess.
President Nicolas Maduro's new constituent assembly - which can rewrite the constitution and could override the opposition-controlled parliament - has been widely criticised as anti-democratic.